Anticancer, antimicrobial, anti-inflammatory, and neuroprotective effects of bisdemethoxycurcumin: Micro and nano facets

In recent years, various approved drugs have been developed deriving from natural sources with potential therapeutic applications. Among these natural metabolites, curcuminoids as phenolic compounds related to Turmeric have obtained great attention. Three main curcuminoids are bisdemethoxycurcumin, demethoxycurcumin, and curcumin with a variety of therapeutic potentials. These polyphenols exhibited numerous therapeutic activities involving anti-acidogenic, antioxidant, anti-inflammatory, anticancer, neuroprotective, antimicrobial, and radioprotective. Low bioavailability is the major limitation of these metabolites that can be ameliorated by novel biocompatible and bioavailable formulations. It must be noted that there are few investigations related to bisdemethoxycurcumin compared to curcumin and demethoxycurcumin, which we have discussed this metabolite in both micro and nanoformulations.