Title of article :
Anti-diabetic, anti-inflammatory, antioxidant, anticancer, antimicrobial, and tissue engineering applications of genipin compound in micro- and nanoformulations: A mini-review
Author/Authors :
Taheri ، Zahra Department of Biology - Islamic Azad University, Tehran Science and Research Branch , Hajimolaai ، Mohammad Department of Pharmacy, Laboratory of Pharmaceutical Technology - University of Patras , Vafaei ، Matin Department of Bioprocess Engineering - School of Bioengineering, College of interdisciplinary Science and Technology - University of Tehran
Abstract :
Genipin as an iridoid monoterpenoid and excellent natural cross-linker can be extracted from Genipa Americana. This metabolite with suitable biocompatibility compared to chemical cross-linking agents such as glutaraldehyde and formaldehyde has been employed to cross-link hydrogels and nanocomposites composed of collagen, chitosan, proteins, and gelatin. Furthermore, therapeutic activities including anti-inflammatory, antioxidant, anticancer, and antimicrobial activities have been reported for this monoterpenoid. Several biomedical limitations involving few available sources, difficulties of extraction, and high cost have been indicated for genipin. In this mini-review, the anti-diabetic, anti-inflammatory, antioxidant, anticancer, antimicrobial, and tissue engineering applications of this herbal metabolite in micro- and nanoformulations have been discussed regarding its limitations.
Keywords :
Iridoid monoterpenoid , Natural cross , linkers , Therapeutic applications , Nanoformulations
Journal title :
Micro Nano Bio Aspects
Journal title :
Micro Nano Bio Aspects
