Title of article :
The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors
Author/Authors :
Abd-El-Fatah ، Samaa Salah Department of Anatomy and Embryology - College of Medicine - Zagazig University , Fathy ، Maha A. Department of Medical Physiology - College of Medicine - Zagazig University , Alabiad ، Mohamed Ali Department of Pathology - Faculty of Medicine - Zagazig University , Aljafil ، Raja Department of Pathology - Faculty of Medicine - University of Benghazi , Gobran ، Mai Ahmed Department of Pathology - Faculty of Medicine - Zagazig University , Ahmad ، Enssaf A. Department of Anatomy and Embryology - College of Medicine - Zagazig University , Alsharidah ، Ashwag S. Department of Physiology - College of Medicine - Qassim University , Alorini ، Mohammed Department of Pathology - College of Medicine - Qassim University , Alnasser ، Sulaiman Mohammed Department of Pharmacology and Toxicology - College of Pharmacy - Qassim University , Awadh ، Sara A. Department of Biochemistry - College of Science and Art - King Abdelaziz University , Morgan ، Enas N. Department of Medical Physiology - College of Medicine - Zagazig University
Abstract :
Background: The risk of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) is estimated to be far greater than that in the general population. Adropin regulates endothelial function and may play a role in the pathogenesis of CVD. Angiotensin-converting enzyme inhibitor (ACEI) treatment was reported to have a protective effect on both renal and cardiovascular function. This study investigated whether adropin is associated with renal and cardiovascular outcomes after using ACEI treatment in CKD rats. Methods: In 2021, in Zagazig, Egypt, rats were assigned to: GI, control group (n=8); GII, CKD group (n=8), and GIII, CKD+captopril group (n=8), in which CKD rats received 100 mg/Kg/day captopril orally. Adropin levels, renal function, blood pressure, and various CVD risk factors were measured. Renal, cardiac, and aortic tissues were examined histologically and immunohistochemically to detect the expression of vascular endothelial growth factor receptor-2 (VEGFR-2). To analyze data, ANOVA and Pearson’s correlation tests were used (SPSS version 18, P 0.05 is significant).Results: Adropin was significantly lower in GII than in GI and GIII (P 0.001). Adropin in GII and GIII was negatively correlated with atherogenic index (P=0.019 and P=0.001, respectively), atherogenic co-efficient (P=0.012 and P=0.013, respectively), troponin I (P=0.021 and P=0.043, respectively), and nitric oxide (P=0.025 and P=0.038, respectively). VEGFR-2 expression decreased in GII and was elevated in GIII (P 0.001).Conclusion: Adropin levels were significantly correlated with most CVD risk factors in CKD and captopril-treated CKD rats, indicating a role for adropin in the pathogenesis of CVD in CKD. It also refers to its implication in the ameliorative effect of ACEI treatment, possibly by affecting VEGFR-2 and nitric oxide release.
Keywords :
Adropin , Renal insufficiency , Chronic kidney disease , Heart disease risk factors , Peptidyl , dipeptidase A
Journal title :
Iranian Journal of Medical Sciences (IJMS)
Journal title :
Iranian Journal of Medical Sciences (IJMS)
