Title of article :
Different Gene Expression Patterns of IL-1 Family Members in Parkinson s Disease: Results from Bayesian Regression Model
Author/Authors :
Jafariaghdam ، Negin Department of Immunology - School of Medicine - Hamadan University of Medical Sciences , Khoshmirsafa ، Majid Department of Immunology - School of Medicine - Iran University of Medical Sciences , Zamani ، Alireza Department of Immunology - School of Medicine - Hamadan University of Medical Sciences , Talebi-Ghane ، Elahe Modeling of noncommunicable Diseases Research Center - Hamadan University of Medical Sciences , Moradi ، Shadi Dept of Immunology - School of Medicine - Hamadan University of Medical Sciences , Shahba ، Faezeh Department of Immunology - School of Medicine - Iran University of Medical Sciences , Mazdeh ، Mehrdokht Department of Neurology - School of Medicine - Hamadan University of Medical Sciences , Eftekharian ، Mohammad Mahdi Department of Immunology - School of Medicine, Neurophysiology Research Center - Hamadan University of Medical Sciences
Abstract :
Parkinson s disease, the second most prevalent neurodegenerative disorder lacking a recognized etiology, is influenced by oxidative stress and alterations in inflammatory cytokine levels. This study aimed to investigate the expression levels of Interleukin(IL)1 receptor accessory protein (IL-1RAcP), IL1β, IL1α, IL33, and IL36 genes in blood cells and serum IL-1β levels in Parkinson s disease patients compared to healthy controls (HCs). In this case-control study, 44 Parkinson s disease patients and 44 age- and sex-matched HCs were included. Gene expression levels were assessed using Quantitative Real-time PCR, and serum IL-1β levels were measured via enzyme-linked immunosorbent assay. Advanced statistical analyses using the Bayesian regression model in R software were employed. Parkinson s disease patients exhibited elevated expression levels of IL-1RAcP and IL1β genes but decreased levels of IL1α, IL33, and IL36 compared to HCs. Age-based differences were not significant. Regarding gender, IL33 transcript levels were significantly higher in males, and serum IL-1β levels were increased in patients. Subgroup analysis by gender indicated alterations in IL1β and IL-1RAcP expression in both genders, while IL1α, IL33, and IL36 showed reduced expression only in males. Remarkably, only female patients displayed significantly higher serum IL-1β levels than female HCs. These findings suggest that dysregulation of immune-related factors plays a crucial role in Parkinson s disease.
Keywords :
Interleukin , 1 receptor accessory protein , Interleukin , 1 , Interleukin , 33 , Interleukin , 36 , Parkinson disease
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
Journal title :
Iranian Journal of Allergy, Asthma and Immunology