The effects of common carp, Cyprinus carpio skin collagen extract on infected wounds

The current study was conducted to evaluate the healing aspect of skin fish collagen on the infected wound in local rabbits. A total of 16 mature animals were divided equally as control and treated groups. Lidocaine 2 % subcutaneously was used as a local anesthetic at the operative site, followed by surgical incision bout 3*4 cm induced full skin wound. Then, the wounds were contaminated with Staphylococcus aureus. After 24hr to 7 days of treatments, the results of temperature, respiration, and heart rates showed a significant difference between the two groups. Furthermore, the photographic scar aggregation in treated groups’ wounds appears less than in the control one. The histological results of the skin biopsies on the seventh and 21st days postoperative in the control group revealed extensive tissue necrosis and hemorrhage, and highly cellular granulation tissue, respectively. Whereas in the treated group on the 7th-day and 21st days post-operation, the histopathological sections revealed good epithelization with early granulation tissue formation characterized, excellent epithelization with a small amount of keratin on the surface, respectively. It was concluded that common carp skin collagen has a good therapeutically antibacterial and anti-inflammatory effect in wound healing.