Title of article :
Recent Advances in the Treatment of Spinal Cord Injury
Author/Authors :
Yari ، Davood Department of Clinical Biochemistry - Babol University of Medical Sciences , Saberi ، Arezoo Department of Pharmaceutics - School of Pharmacy - Mashhad University of Medical Sciences , Salmasi ، Zahra Department of Pharmaceutical Nanotechnology - Department of Pharmaceutical Nanotechnology - Nanotechnology Research Center, Pharmaceutical Technology Institute, School of Pharmacy - Mashhad University of Medical Sciences, Mashhad University of Medical Sciences , Ghoreishi ، Alireza Department of Orthopedic Surgery - Orthopedic Research Center, Faculty of Medicine - Mashhad University of Medical Sciences , Etemad ، Leila Pharmaceutical Research Center, Pharmaceutical Technology Institute - Mashhad University of Medical Sciences , Movaffagh ، Jebrail Department of Pharmaceutics - School of Pharmacy, Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute - Mashhad University of Medical Sciences , Ganjeifar ، Babak Department of Neurosurgery - Ghaem Hospital - Mashhad University of Medical Sciences
Abstract :
Spinal cord injury (SCI) is a complex, multifaceted, progressive, and yet incurable complication that can cause irreversible damage to the individual, family, and society. In recent years strategies for the management and rehabilitation of SCI besides axonal regeneration, remyelination, and neuronal plasticity of the injured spinal cord have significantly improved. Although most of the current research and therapeutic advances have been made in animal models, so far, no specific and complete treatment has been reported for SCI in humans. The failure to treat this complication has been due to the inherent neurological complexity and the structural, cellular, molecular, and biochemical characteristics of spinal cord injury. In this review, in addition to elucidating the causes of spinal cord injury from a molecular and pathophysiological perspective, the complexity and drawbacks of neural regeneration that lead to the failure in SCI treatment are described. Also, recent advances and cutting -edge strategies in most areas of SCI treatment are presented. Level of evidence: I
Keywords :
Combination therapy , Neural tissue engineering , Neuron , SCI , Spinal cord injury
Journal title :
The Archives of Bone and Joint Surgery
Journal title :
The Archives of Bone and Joint Surgery
