Title of article :
Freeze-Dried Dentin Derivative Signal as a Factor for Differentiation of Human Dental Pulp Stem Cells: An In Vitro Study
Author/Authors :
Jalili Sadrabad ، Maryam Department of Oral and Maxillofacial Medicine - School of Dentistry - Semnan University of Medical Sciences , Sameni ، Hamid Reza Department of Tissue Engineering and Applied Cell Sciences - Nervous System Stem Cells Research Center, School of Medicine - Semnan University of Medical Sciences , Zarbakhsh ، Sam Department of Anatomical Sciences - Nervous System Stem Cells Research Center, School of Medicine - Semnan University ofMedical Sciences , Ghorbani ، Raheb Department of Epidemiology and Biostatistics - School of Medicine, Social Determinants of Health Research Center - Semnan University of Medical Sciences , Naghipoor ، Amin Student Research Committee, School of Dentistry - Semnan University of Medical Sciences , Jarahi ، Alireza Student Research Committee, School of Dentistry - Semnan University of Medical Sciences , Mohiti ، Azra Department of Oral and Maxillofacial Medicine - Dental School - Alborz University of Medical Sciences
Abstract :
Tissue engineering is an emerging field in dentistry, and stem cell research has shown promise in regenerating new tissue. The three essential components for tissue engineering are stem cells, scaffolds, and growth/differentiation factors. Numerous studies have been conducted in regenerative medicine, and more recently in regenerative dentistry, utilizing different signals. In a pioneering study, dentin derivative signal (DDS), which was self-administered, was used as a differentiation factor for dental pulp stem cells to promote dentinogenesis in vitro. The study demonstrated that DDS can stimulate dental pulp stem cells to differentiate into other dental tissues, such as dentin.
Keywords :
Dental Stem Cells , Regeneration , Signal , Regenerative Dentistry
Journal title :
Shiraz E Medical Journal
Journal title :
Shiraz E Medical Journal
