A FRET Study of Guest Delivery to Concanavaline A by Supramolecular Hosts Composed of an Adamantyl-Appended Cyclophane and Saccharide-Branched Cyclodextrins

Water-soluble supramolecular hosts composed of an adamantyl-appended cyclophane and glucosyl- or maltosyl-(alpha)cyclodextrins were developed as a transporter for fluorescent guest toward Concanavaline A (Con A), (alpha)-D-glucoside-binding lectin. The delivery of perylene as a model guest from aqueous media to Con A surfaces was monitored by fluorescence resonance energy transfer (FRET) spectroscopy.