A Facile Synthesis of Optically Active 1,1,1-Trifluoro-3-alkyn-2-ols by Stereospecific Substitution of Optically Active 1-Benzyloxy-2,2,2-trifluoroethyl Tosylate with Lithium Alkynyltriethylaluminates

Optically active l-benzyloxy-2,2,2-trifluoroethyl tosylate reacts with various lithium alkynyltriethylaluminates to give optically active 2-benzyloxy-l,l,l-trifluoro-3-alkynes selectively and stereospecifically with inversion of configuration. Thus, the reaction provides with a novel method for the preparation of various optically active l,l,l-trifluoro-3-alkyn-2-ols.