Synthesis and Optical Resolution of Novel Chiral Silanols

Silanols bearing an asymmetric center on silicon, methyl(2-phenylethenyl)(3,3,3-trifluoropropyl)silanol and methyl(phenyl)(vinyl)silanol are synthesized by alkylative cleavages of cyclic siloxanes with an organolithium. Optical resolution of their enantiomers is performed by HPLC with a chiral stationary phase column. Optical characters of thus separated enantiomers are also examined.