Title of article
3-Isopropylidenemalic Acid: A Mechanism-based Inhibitor of 3-Isopropylmalate Dehydrogenase
Author/Authors
Chiba، Akira نويسنده , , Arai، Noriko نويسنده , , Eguchi، Tadashi نويسنده , , Kakinuma، Katsumi نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
-1312
From page
1313
To page
0
Abstract
3-Isopropylidenemalic acid (1) was designed and synthesized as an inhibitor of 3-isopropylmalate dehydrogenase (IPMDH). While being weakly active as substrate, 1 appeared to be a mechanism-based inhibitor (KI = 60.2 (mu)M) for IPMDH as deduced from the time-dependent and kinetic analyses.
Keywords
Goodness of fit , Restricted latent class models , Model diagnosis , Identifiability , Parametric bootstrap
Journal title
CHEMISTRY LETTERS
Serial Year
1999
Journal title
CHEMISTRY LETTERS
Record number
28232
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