Title of article :
3-Isopropylidenemalic Acid: A Mechanism-based Inhibitor of 3-Isopropylmalate Dehydrogenase
Author/Authors :
Chiba، Akira نويسنده , , Arai، Noriko نويسنده , , Eguchi، Tadashi نويسنده , , Kakinuma، Katsumi نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Abstract :
3-Isopropylidenemalic acid (1) was designed and synthesized as an inhibitor of 3-isopropylmalate dehydrogenase (IPMDH). While being weakly active as substrate, 1 appeared to be a mechanism-based inhibitor (KI = 60.2 (mu)M) for IPMDH as deduced from the time-dependent and kinetic analyses.
Keywords :
Goodness of fit , Restricted latent class models , Model diagnosis , Identifiability , Parametric bootstrap
Journal title :
CHEMISTRY LETTERS
Journal title :
CHEMISTRY LETTERS
