Solid Phase Synthesis of Hydroxy Benzothiazepinones through Cyclative Release under Thermolysis

Hydroxy benzothiazepinones were synthesized by a simple procedure involving epoxidation of polymer bound cinnamic acids followed by nucleophilic opening of the resulting glycidic ester by o-aminothiophenol to afford the intermediate hydroxy anilinoesters which underwent cyclization cleavage on heating in DMF to release the product completely.