Conversion of 3-O-Substituted 1,2-Dibromoalkanes into 2-Bromo-1-alkenes by the Selective Elimination: Its Application to Total Synthesis of 12-Oxygenated Tremetones

2-Bromo-1-alkenes were efficiently synthesized in good yields by the regioselective HBr-elimination reaction of 3-aryloxy- or 3-acyloxy-1,2-dibromoalkanes. Total synthesis of several oxygenated tremetones has been accomplished by using the 2-bromo-1-alkene derivative produced by this elimination reaction.