A Novel L-Proline Catalyzed Biginelli Reaction: One-Pot Synthesis of 3,4-Dihydropyrimidin-2 (1H)-ones under Solvent-Free Conditions

A Novel efficient and simple synthetic protocol for the Biginelli reaction has been developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones in a one-pot three-component condensation of aldehydes, (beta)-dicarbonyl compounds, and urea or thio-urea by using 10 mol % L-proline as the catalyst under solvent free condition.