Self-assembly of Tetramethylated Resorcin[4]arene to Form Molecular Capsules Incorporating Methanol, Ethanol, and Imidazole: A Comparison with the Unsubstituted Resorcin[4]arene System

Tetramethylated resorcin[4]arene (MRCT) forms ʹhead-to-headʹ arranged self-dimers incorporating neutral guest molecules methanol, ethanol, and imidazole within the cavity, with the MRCT:guest composition of 2:2, while unsubstituted resorcin[4] arene forms 1:1 monomers, showing the significance of the methyl substituents of the MRCT rings in the capsule formation through methyl···methyl hydrophobic interactions between the facing substructures, as evidenced by X-ray diffraction.