Microwave Assisted Facile One-Pot Synthesis of 188Re-Complex Using a Tetrahydroborate Exchange Resin. A Bifunctional Chelating Agent for Radiopharmaceuticals

A facile one-pot synthesis of 188Re-complex as a bifunctional chelating agent for the preparation of therapeutic radiopharmaceuticals was accomplished with good labeling yields and radiochemical purity by using a tetrahydroborate exchange resin as a reducing agent for a disulfide ligand as well as the [188Re]perrhenate ion under microwave irradiation.