Author/Authors :
VOS، A. F. DE نويسنده , , Santens، P. نويسنده , , Slegers، G. نويسنده , , Vermeirsch، H. نويسنده , , Dewolf، I. نويسنده , , Dumont، F. نويسنده , , Dierckx، R. A. نويسنده , , Reuck، J. De نويسنده ,
Abstract :
Donepezil is a highly potent and selective reversible achetylcholinesterase inhibitor. [11C] Donepezil is prepared by methylation with [11C]CH3I of the corresponding 6ʹ-Odesmethylprecursor. Tissue distribution in mice revealed a high uptake in brain and rapid clearance from the blood. Metabolization studies in mice indicated the formation of one 11Clabeled polar metabolite that didnʹt penetrate the blood-brain barrier. Regional brain distribution in rabbits didnʹt reflect the measured achetylcholinesterase distribution in rabbit brain.
Keywords :
18F , Acetylcholinesterase , Alzheimers disease , 4-fluorodonepezil
