Title of article
Comparison of animal models for the evaluation of radiolabeled androgens
Author/Authors
Welch، Michael J. نويسنده , , Katzenellenbogen، John A. نويسنده , , Jones، Lynne A. نويسنده , , Downer، Joanna B. نويسنده , , Engelbach، John A. نويسنده , , Lich، Lennis L. نويسنده , , Mao، Wang نويسنده , , Carlson، Kathryn E. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
-612
From page
613
To page
0
Abstract
Biodistribution of two 18F-labeled androgens and an 124I/125I-labeled androgen were studied in five androgen receptor (prostate) animal models with or lacking sex hormone binding globulin (SHBG). As models for androgen-receptor positive ovarian cancer, xenografts of three human ovarian cancer cell lines were tested in SCID mice. SHBG in the prostate model systems significantly affects the metabolism, clearance, and distribution of the radiolabeled androgens in several tissues, but ovarian cancer animal models were disappointing.
Keywords
Peptides , thrombosis , Pulmonary embolism , Disintegrins , Platelet aggregation inhibitors , Crotalid venoms
Journal title
NUCLEAR MEDICING & BIOLOGY
Serial Year
2001
Journal title
NUCLEAR MEDICING & BIOLOGY
Record number
29600
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