A Strategy for Increasing the Brain Uptake of a Radioligand in Animals: Use of a Drug that Inhibits Plasma Protein Binding

It is shown that the Piagetian model of stagewise cognitive development can be assigned a powerful causal interpretation in terms of self-organizing epigenetic processes. A detailed heuristic explanation is given of self-organizing epigenetics. In addition, the relationships between selforganizing epigenetics on the one hand, and traditional genetical and environmental accounts of cognitive development on the other hand, are scrutinized. Special emphasis is given to fundamental limitations of causal accounts of cognitive development in terms of the now popular artificial neural networks. To further study these limitations, a paradigm based on Kantʹs transcendental psychology is proposed.