Experimentally induced cholangiohepatopathy by dosing sheep with fractionated extracts from Brachiaria decumbens

Cholangiohepatopathy was induced in 5 lambs by oraJ administration of extracts from signal grass (Brachiaria decumbens) in Brazil. Grossly there were pale foci multifocally distributed throughout the hepatic parenchyma in 4 lambs. The microscopic changes, which were similar to those produced by other steroidal sapogenins-containing plants such as Tribulus terrestris and Panicum spp., included multifocal cholangitis, bile duct proliferation, and the presence of crystals in the biliary system.