Kinetics of reaction of chloroacetone with thioureas

The second order rate constants for the reactions of chloroacetone with thiourea, phenylthiourea and p-substituted phenylthioureas have been evaluated in ethanol medium. The rate of reaction is first order with respect to chloroacetone and first order with respect to thioureas. The effect of substituents on the rate of reaction is also studied. Thermodynamic parameters are used to explain the nature of reaction. Possible mechanism for the reaction is suggested.