MODIFIED BOROHYDRIDE REAGENTS AND THEIR APPLICATIONS IN ORGANIC SYNTHESIS

In this article the development of modified borohydride reagents in the last three decades Aand their applications in organic synthesis are reviewed. 1. Historical Background 2. Mechanism of NaBH4 and LiAlH4 Reactions 3. Simple Alkali Metal and Modified Borohydrides 3.1. Hydride Exchange 3.2. Alkali Metal and Metal Cation Exchanges 3.3. Concurrent Cation and Hydride Exchanges 3.4. Ligand-Metal Borohydrides 3.5. Borohydride Combination Systems 3.6. Quaternary Ammonium Borohydrides 3.7. Polymer Supported Borohydrides 4. Zinc and Zirconium Borohydrides