Title of article :
Freehand core biopsy in breast cancer: an accurate predictor of tumour grade following neoadjuvant chemotherapy?
Author/Authors :
S. A. McIntosh، نويسنده , , L. Panchalingam، نويسنده , , S. Payne، نويسنده , , I. D. Miller، نويسنده , , T. K. Sarkar، نويسنده , , A. W. Hutcheon، نويسنده , , S. D. Heys، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
5
From page :
496
To page :
500
Abstract :
Core biopsy is an increasingly used technique in the pre-operative diagnosis of breast carcinoma, as it provides useful prognostic information with respect to tumour type and grade. Neoadjuvant chemo-therapy is being used in the treatment of large and locally advanced breast cancers but little is known regarding the correlation between tumour histology on pre-treatment core biopsy and that in residual tumour following primary chemotherapy and surgery. This study aimed to evaluate the accuracy of core biopsy in predicting these features in patients treated with primary chemotherapy. One hundred and thirty-three patients with carcinoma of the breast diagnosed on clinical, radiological and cytological examination underwent core biopsy, followed by primary chemotherapy (with cyclophosphamide, vincristine, doxorubicin and prednisolone) and surgery. The false-negative rate for pre-treatment core biopsy was 14%, with 91% agreement between the grade demonstrated on core biopsy and that in the residual tumour following completion of chemotherapy. Tumour type in the residual post-chemotherapy tumour was predicted by core biopsy in 84%. This study suggests that pre-treatment core biopsy histology accurately predicts residual tumour histology following primary chemotherapy and surgery in patients with breast cancer.
Journal title :
The Breast
Serial Year :
2002
Journal title :
The Breast
Record number :
454511
Link To Document :
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