Primary carcinoma of breast with small-cell differentiation

We present a case of primary carcinoma of breast with neuro-endocrine small-cell features in a 58-year-old female. To the best of our knowledge this is the first reported case of this kind in the UK. The patient had regional nodal metastasis. She underwent breast conserving surgery and adjuvant chemotherapy. Immunocytochemistry was positive for neuro-endocrine origin of the tumour. We review the literature.