Author/Authors :
Leticia Llanes-Fern?ndez، نويسنده , , Rosa Irene ?lvarez-Goyanes، نويسنده , , Maria del Carmen Arango-Prado، نويسنده , , Juan Manuel Alcocer-Gonz?lez، نويسنده , , Julia Cruz Mojarrieta، نويسنده , , Xiomara Escobar Pérez، نويسنده , , Maiby Orozco L?pez، نويسنده , , Sonia Franco Odio، نويسنده , , Rolando Camacho-Rodr?guez، نويسنده , , Marta Elena Guerra-Yi، نويسنده , , Vicente Madrid-Marina، نويسنده , , Reyes Tamez-Guerra، نويسنده , , Cristina Rodr?guez-Padilla، نويسنده ,
Abstract :
Tumor markers are expressed due to molecular alterations of the tumor cells, and we can relate them to the immune system to find new associations to improve prognosis. IL-10 inhibits the generation of immune responses at the tumor site. To determine IL-10 expression in the tumor microenvironment and to associate it with certain tumor markers, 27 breast cancer patients were monitored by immunohistochemistry. The results showed that 23 breast cancer samples exhibited a strong expression of IL-10. IL-10 was associated with some poor prognosis tumor makers. A direct association between IL-10, Bcl-2, and Bax was detected. The relationship between IL-10 and Bax was statistically significant (P=0.001). An inverse association of IL-10 with p53 was observed. IL-10 reflects a suppressive tumor microenvironment, and its relationship with apoptosis markers can suggest an increase in the aggressiveness of the tumor even if it still is at an early stage.
Keywords :
breast cancer , BcL-2 family , p53 , HER-2 , ER , IL-10
