Association of dopamine-β-hydroxylase and androgen receptor gene polymorphisms with Eysenck’s P and other personality traits

Biological theories of the personality trait of psychoticism (P) have proposed roles for low dopamine-β-hydoxylase and high testerosterone. It was therefore predicted that polymorphisms of the dopamine-β-hydroxylase and androgen receptor genes would be associated with P. Data were taken from a community survey of Australian adults who completed personality questionnaires and gave a DNA sample. 896 participants were genotyped for dopamine-β-hydroxylase C-1021T polymorphism, and 1676 and 1698 were genotyped for androgen receptor CAG and GGC repeat polymorphisms respectively. Males with short CAG alleles were found to have significantly higher P scores, but no other associations with P were found. Given the statistical power of the study, if there are associations with the polymorphisms investigated, they must be very small.