Reproducibility of Chronic and Acute Infarct Size Measurement by Delayed Enhancement-Magnetic Resonance Imaging Original Research Article

Reproducibility of Chronic and Acute Infarct Size Measurement by Delayed Enhancement-Magnetic Resonance Imaging Original Research Article Pages 1641-1645 Holger Thiele, Mathias J.E. Kappl, Stefan Conradi, Josef Niebauer, Rainer Hambrecht, Gerhard Schuler Close Close preview | PDF (164 K) | Related articles | Related reference work articles AbstractAbstract | Figures/TablesFigures/Tables | ReferencesReferences Objectives The aim of this study was to evaluate the reproducibility of acute and chronic infarct size (IS) by delayed enhancement (DE) magnetic resonance imaging (MRI). Background Infarct size measurements can be used as surrogate end point to reduce the sample size in studies comparing different reperfusion strategies in myocardial infarction (MI). Delayed enhancement MRI is a rather new technique, and so far infarct IS reproducibility has not been established appropriately. Methods In 21 patients (10 acute MI and 11 chronic MI), IS was assessed repeatedly on consecutive days by DE-MRI. Reproducibility, interobserver, and intraobserver variabilities were assessed and compared by the Bland-Altman method. Results Acute and chronic IS were 17.1 ± 19.6% (range 5.1% to 69.8%) of LV mass (%LV) and 16.9 ± 9.9 %LV (range 2.0% to 36.0%), respectively. Infarct size difference (bias) between scan I and scan II was −0.5 %LV, and limits of agreement were ±2.4 %LV. Mean bias (−0.7 %LV) and limits of agreement (±3.2%) were slightly higher for acute in comparison with chronic MI with −0.4 ± 1.3 %LV. Intraobserver and interobserver variability was low with a mean bias of 0.3 %LV (limits of agreement ± 1.7 %LV) and −0.7 %LV (limits of agreement ± 2.2 %LV), respectively. Conclusions Infarct size measurement by DE-MRI is an excellent tool for IS assessment, owing to its excellent repeatability in chronic and acute MI. It has therefore the potential to serve as a surrogate end point to uncover advantages of new reperfusion strategies. Article Outline Methods Study population MRI Image analysis Statistical analysis Results Reproducibility of MRI Interobserver and intraobserver variability Discussion Reproducibility of MRI Accurate infarct sizing by MRI Infarct size end point use in clinical trials Sample size calculation Study limitations Conclusions References