A Prospective Study of Green Tea Consumption and Oral Cancer Incidence in Japan

Purpose To examine the relation of green tea consumption with oral carcinogenesis, we prospectively analyzed data from a nationwide large-scale cohort study in Japan. Methods A total of 20,550 men and 29,671 women aged 40–79 years, without any history of oral and pharyngeal cancer at baseline survey, were included in the present study. During a mean follow-up period of 10.3 years, 37 oral cancer cases were identified. The Cox proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (95% CI) for oral cancer according to green tea consumption by sex, while adjusting for age, smoking, alcohol drinking, and other dietary factors. Results For women, the HRs of oral cancer for green tea consumption of 1–2, 3–4, and 5 or more cups per day were 0.51 (95% CI: 0.10–2.68), 0.60 (95% CI: 0.17–2.10), and 0.31 (95% CI: 0.09–1.07), respectively, compared with those who drank less than one cup per day (p for trend, 0.08). For men, no such trends were observed. Conclusions Our findings did not suggest a prominent inverse association of green tea consumption with oral cancer, although there was a tendency for a reduced risk in women.