Title of article :
A Prospective Cohort Study of Rectal Cancer Risk in Relation to Active Cigarette Smoking and Passive Smoke Exposure
Author/Authors :
Craig M. Hooker، نويسنده , , Lisa Gallicchio، نويسنده , , Jeanine M. Genkinger، نويسنده , , George W. Comstock، نويسنده , , Anthony J. Alberg، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
8
From page :
28
To page :
35
Abstract :
Purpose The present investigation prospectively examined active cigarette smoking and household passive smoke exposure and the risk of developing rectal cancer. Methods Cigarette smoking data were collected on all household members during two private censuses in Washington County, Maryland. These two cohorts were followed up, one cohort from 1963–1978 and the other from 1975–1994 for first-time diagnoses of rectal cancer. We identified 148 and 169 rectal cancer cases in the 1963 and 1975 cohorts, respectively. Relative risks were estimated by means of Poisson regression models. Results In men, the adjusted relative risks (aRR) and 95% confidence intervals (CI) for the association between current smoking and rectal cancer were 3.1 (1.2–7.8) in the 1963 cohort and 1.8 (0.9–3.7) in the 1975 cohort; the corresponding aRRs in women were 0.9 (0.5–1.8) and 1.6 (0.9–3.8) in the 1963 and 1975 cohorts, respectively. In nonsmokers, household passive smoke exposure was strongly associated with rectal cancer among men in the 1963 cohort (aRR = 5.8; 1.8–18.4) but not the 1975 cohort (aRR = 1.1; 0.2–5.0). In women, household passive exposure was not strongly associated with rectal cancer in either cohort. Conclusions The results of our study suggest that active cigarette smoking may contribute to rectal cancer risk, but inconsistencies in the findings preclude drawing strong, clear-cut inferences.
Keywords :
cigarette smoking , Prospective study , Secondhand smoke , rectal cancer , Passive Smoke
Journal title :
Annals of Epidemiology
Serial Year :
2008
Journal title :
Annals of Epidemiology
Record number :
463081
Link To Document :
بازگشت