Electrophysiological comparison between corticobasal degeneration and progressive supranuclear palsy

Multimodal evoked potentials were recorded in four patients with corticobasal degeneration (CBD), four patients with progressive supranuclear palsy (PSP) and 15 normal control subjects. CBD and PSP patients showed significant prolongation of the N200 and P300 latencies of auditory event-related potentials compared with controls. Patients with CBD showed significant prolongation of interpeak latencies between N13 and N20 of short-latency somatosensory evoked potentials compared with the controls and patients with PSP. The present results show that the two diseases have different electrophysiologic features.