Title of article
Phyto-oestrogens
Author/Authors
Alison M. Duncan، نويسنده , , William R. Phipps، نويسنده , , Mindy S. Kurzer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
19
From page
253
To page
271
Abstract
Phyto-oestrogens are oestrogenic compounds found in plants and consist of isoflavones, lignans and coumestans. Epidemiological studies provide evidence for a protective role of isoflavones, and to a lesser extent lignans, against the development of numerous chronic diseases, including several cancers, cardiovascular disease and osteoporosis. The structural similarity of phyto-oestrogens to endogenous oestrogens has prompted the hypothesis that phyto-oestrogens exert hormonal or anti-hormonal effects relevant to the risk of hormone-dependent disease and/or their suitability as a dietary alternative to hormone replacement therapy. The many human studies that have evaluated the effects of isoflavones and lignans on various endpoints relating to risk of various diseases have greatly increased knowledge of how these compounds behave. At the same time, additional questions have been generated. For example, the increasing interest in extracting isoflavones from the soybean for incorporation into dietary supplements has raised important concerns regarding safety and efficacy. Overall, it is clear that phyto-oestrogens are an area of active and advancing research with great potential to continue to affect human health
Keywords
osteoporosis , safety , cancer , health effects , Review , isoflavone , lignan , CardiovascularDisease , phyto-oestrogen , menopausal symptoms
Journal title
Best Practice and Research Clinical Endocrinology and Metabolism
Serial Year
2003
Journal title
Best Practice and Research Clinical Endocrinology and Metabolism
Record number
465901
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