Assessing the activity of rheumatoid arthritis

Summary Disease activity in rheumatoid arthritis is not easily measured. The validity of current measures has been reviewed. Recent international efforts have resulted in consensus over a minimum (WHO/ILAR) core set of endpoints in RA trials: pain, patient and physician (assessor) global assessment, physical disability, swollen joint count, tender joint count, acute phase reactants; and for studies of one or more yearsʹ duration: radiographs of joints. The near future will hopefully see validation of new measures, also in terrains not currently covered by the core set.