Title of article :
Mobilization of peripheral blood progenitor cells for autografting: chemotherapy and G-CSF or GM-CSF
Author/Authors :
S. Siena، نويسنده , , M. Bregni، نويسنده , , A. M. Gianni، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
13
From page :
27
To page :
39
Abstract :
The mobilization of haematopoietic progenitor cells is a multifactorial process, still poorly understood at the molecular level. Mobilized haematopoietic progenitors, as defined by the expression of CD34 cell surface molecule, comprise heterogeneous subpopulations of cells committed to different haematopoietic lineages. Haematopoietic progenitors may be mobilized by chemotherapy alone, haematopoietic growth factors alone, or by chemotherapy plus haematopoietic growth factors. The choice of a mobilization regimen that allows an optimal yield of progenitors with a minimum number of leukaphereses should incorporate, in most patients, a disease-specific chemotherapeutic agent(s) plus a haematopoietic growth factor, to be continued until completion of harvest.
Keywords :
GM-CSF , Filgrastim , Mobilization , G-CSF , CD34+ cells , haematopoietic progenitor cells , lenograstim , molgramostim , sargramostim.
Journal title :
Best Practice and Research Clinical Haematology
Serial Year :
1999
Journal title :
Best Practice and Research Clinical Haematology
Record number :
467325
Link To Document :
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