Author/Authors :
John F. Martin، نويسنده , , Russell E. A. Smith، نويسنده , , Anthony Mathur، نويسنده ,
Abstract :
Platelets are one of the most important components of primary haemostasis. Since they lack a nucleus, their functional characteristics are determined at the time of production. The role of platelets in thrombosis is further modified by the interaction with vascular mediators that are endogenously produced in response to a variety of stimuli.
This chapter discusses the factors that influence platelet production, the interaction with endogenous mediators, and the potential therapeutic benefits achieved by modifying this interaction in the clinical setting.
Keywords :
endothelin , nitric oxide , prostacyclin , Interleukin 3 , platelet , interleukin 6 , tissue factor pathway inhibitor , cGMP , tissue factor , : cAMP , endogenous mediators , ®brinogen , 5-hydroxytrypta-mine , interleukin 1b , megakaryocyte , nitric oxidesynthase , plasminogen , platelet derived growth factor , thromboxane A2 , thrombopoiesis , tumour necrosis factor a.
