Title of article
Chemotherapy resistance in acute myeloid leukaemia
Author/Authors
Pieter Sonneveld، نويسنده , , Alan F. List، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
23
From page
211
To page
233
Abstract
The development of refractory disease in acute myeloid leukaemia (AML) is frequently associated with the expression of one or several multidrug resistance (MDR) genes. MDR1, MRP1 and LRP have been identified as important adverse prognostic factors in AML. Recently it has become possible to reverse clinical multidrug resistance by blocking P-glycoprotein-mediated drug efflux. The potential relevance of MDR and new approaches to treat refractory disease, are discussed.
Keywords
mdr , multidrug resistance , MRP , P-glycoprotein , LRP , Acute myeloid leukaemia , PSC 833 , cyclosporin.
Journal title
Best Practice and Research Clinical Haematology
Serial Year
2001
Journal title
Best Practice and Research Clinical Haematology
Record number
467418
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