Author/Authors :
Roberto Gerli، نويسنده , , Claudio Lunardi، نويسنده , , Fabrizio Vinante، نويسنده , , Onelia Bistoni، نويسنده , , Giovanni Pizzolo، نويسنده , , Costantino Pitzalis، نويسنده ,
Abstract :
CD30 has been proposed to identify Th0/2-type clones. However, the in vivo relevance of this finding is still a matter of debate, as high serum levels of soluble CD30 have been found in both Th1- and Th2- dominated disorders. Among these, rheumatoid arthritis represents a condition where the Th1 predominance is combined with the presence of CD30+ T-cell activity, particularly in specific stages of the disease. This article discusses the hypothesis that CD30+ T cells might play a counter-regulatory role at sites of inflammation in Th1-mediated conditions, such as rheumatoid arthritis
