Mitochondrial redistribution: adding new players to the chemotaxis game

Leukocyte polarization and chemotaxis have a key role in the homeostasis of the immune system and in inflammation. Recent work shows that chemoattractants induce the redistribution of mitochondria towards the uropod of polarized migrating leukocytes through a mechanism involving microtubules and mitochondrial fission. These findings underscore the key role this organelle can have in leukocyte chemotaxis by fuelling motor proteins at their trailing edge.