Title of article :
Accuracy of In Vivo Coronary Plaque Morphology Assessment: A Validation Study of In Vivo Virtual Histology Compared With In Vitro Histopathology Original Research Article
Author/Authors :
Kenya Nasu، نويسنده , , Etsuo Tsuchikane، نويسنده , , Osamu Katoh، نويسنده , , D. Geoffrey Vince، نويسنده , , Renu Virmani، نويسنده , , Jean-François Surmely، نويسنده , , Akira Murata، نويسنده , , Yoshihiro Takeda، نويسنده , , Tatsuya Ito، نويسنده , , Mariko Ehara، نويسنده , , Tetsuo Matsubara، نويسنده , , Mitsuyasu Terashima، نويسنده , , Takahiko Suzuki، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Objectives
The goal of the present study was to compare the accuracy of in vivo tissue characterization obtained by intravascular ultrasound (IVUS) radiofrequency (RF) data analysis, known as Virtual Histology (VH), to the in vitro histopathology of coronary atherosclerotic plaques obtained by directional coronary atherectomy.
Background
Vulnerable plaque leading to acute coronary syndrome (ACS) has been associated with specific plaque composition, and its characterization is an important clinical focus.
Methods
Virtual histology IVUS images were performed before and after a single debulking cut using directional coronary atherectomy. Debulking region of in vivo histology image was predicted by comparing pre- and post-debulking VH images. Analysis of VH images with the corresponding tissue cross section was performed.
Results
Fifteen stable angina pectoris (AP) and 15 ACS patients were enrolled. The results of IVUS RF data analysis correlated well with histopathologic examination (predictive accuracy from all patients data: 87.1% for fibrous, 87.1% for fibro-fatty, 88.3% for necrotic core, and 96.5% for dense calcium regions, respectively). In addition, the frequency of necrotic core was significantly higher in the ACS group than in the stable AP group (in vitro histopathology: 22.6% vs. 12.6%, p = 0.02; in vivo virtual histology: 24.5% vs. 10.4%, p = 0.002).
Conclusions
Correlation of in vivo IVUS RF data analysis with histopathology shows a high accuracy. In vivo IVUS RF data analysis is a useful modality for the classification of different types of coronary components, and may play an important role in the detection of vulnerable plaque.
Keywords :
radiofrequency , IVUS , DCA , Acute coronary syndrome , RF , AP , intravascular ultrasound , ACS , directional coronary atherectomy , angina pectoris , VH , Virtual Histology
Journal title :
JACC (Journal of the American College of Cardiology)
Journal title :
JACC (Journal of the American College of Cardiology)