Author/Authors :
Rong Zhou، نويسنده , , Paul D. Acton، نويسنده , , Victor A. Ferrari، نويسنده ,
Abstract :
Stem cell–based cellular cardiomyoplasty represents a promising therapy for myocardial infarction. Noninvasive imaging techniques would allow the evaluation of survival, migration, and differentiation status of implanted stem cells in the same subject over time. This review describes methods for cell visualization using several corresponding noninvasive imaging modalities, including magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and bioluminescent imaging. Reporter-based cell visualization is compared with direct cell labeling for short- and long-term cell tracking.
Keywords :
PET , SPECT , positron emission tomography , transferrin receptor , Thymidine kinase , green fluorescent protein , Firefly luciferase , GFP , NIS , TA , USPIO , TK , SPIO , ultrasmall superparamagnetic iron oxide , BMSC , bone marrow-derived mesenchymal stem cell , D2R , dopamine type 2 receptor , ECFP , enhanced cyan fluorescent protein , Fluc , HSV1-tk , herpes simplex virus type 1 thymidine kinase , MLC2v , ventricular myosin light chain 2 , MPIO , micrometer-sized superparamagnetic iron oxide , sodium-iodide symporter , single-photon emission computerized tomography , superparamagnetic iron oxide , transfecting agent , TFR
