Author/Authors :
Nathaniel H. Robin، نويسنده , , Paul B. Tabereaux، نويسنده , , Raymond Benza، نويسنده , , Bruce R. Korf، نويسنده ,
Abstract :
Genetic testing is increasingly becoming possible for diagnosis, susceptibility testing, and prognostication in cardiovascular medicine. The practicing cardiologist, therefore, needs to be familiar with the clinical utilities and limitations of genetic testing. This review explores the major approaches to genetic testing and issues in test interpretation. Specific applications to cardiovascular diseases, including coronary artery disease, cardiomyopathies, cardiac arrhythmias, and pulmonary arterial hypertension are discussed.
Keywords :
myocardial infarction , long QT syndrome , cardiomyopathy , CAD , PAH , hypertrophic cardiomyopathy , coronary artery disease , LDL , low-density lipoprotein , SNP , Single nucleotide polymorphism , Dilated cardiomyopathy , MI , familial hypercholesterolemia , LDLR , RCM , HCM , DCM , PPH , primary pulmonary hypertension , LQTS , pulmonary arterial hypertension , ARVC , restrictive cardiomyopathy , CM , familial dilated cardiomyopathy , low-density lipoprotein receptor , PCCD , progressive cardiac conduction defect , FH , CPVT , catecholaminergic polymorphic ventricular tachycardia , arrythmogenic right ventricular dysplasia/cardiomyopathy , DCM-CCD , dilated cardiomyopathy associated with cardiac conduction defects , FDCM , INVM , isolated noncompaction of the ventricular myocardium
