Title of article
The pathogenetic role of HLA-B27 and its subtypes
Author/Authors
Muhammad Asim Khan، نويسنده , , Alessandro Mathieu، نويسنده , , Rosa Sorrentino، نويسنده , , Nurullah Akkoc، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
183
To page
189
Abstract
The strong association between HLA-B27 and ankylosing spondylitis has been known for more than 33 years, but the enigma of the pathogenetic role of the gene and its product has not yet been solved. Ongoing studies have produced evidence supporting different theories to explain this association, and structural and functional studies of HLA-B27 allele products at molecular level have provided information of broad and multidisciplinary value and disclosed new avenues leading to autoimmunity and immune disregulation.
Keywords
pathogenesis , ankylosing spondylitis , animal models , HLA-B27
Journal title
Autoimmunity Reviews
Serial Year
2007
Journal title
Autoimmunity Reviews
Record number
474749
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