Author/Authors :
Wang، Liman نويسنده , , Liu، Qinghua نويسنده , , Frutos، Anthony G. نويسنده , , Gillmor، Susan D. نويسنده , , Thiel، Andrew J. نويسنده , , Strother، Todd C. نويسنده , , Condon، Anne E. نويسنده , , Corn، Robert M. نويسنده , , Lagally، Max G. نويسنده , , Smith، Lloyd M. نويسنده ,
Abstract :
DNA computing on surfaces is where complex combinatorial mixtures of DNA molecules are immobilized on a substrate and subsets are tagged and enzymatically modified (DESTROY) in repeated cycles of the DNA computation. A restriction enzyme has been chosen for the surface DESTROY operation. For the READOUT operation, both cycle sequencing and PCR amplification followed by addressed array hybridization were studied to determine the DNA sequences after the computations.
Keywords :
Enzyme systems , Transient phase , steady state , Rapid equilibrium , Kinetic equations , Computer program
