Cardiovascular and autonomic nervous functions during acclimatization to hypoxia in conscious rats

The time courses of changes in cardiovascular and autonomic nervous functions during acclimatization to hypoxia were studied in conscious Sprague–Dawley rats. The animals were kept under a 12:12-h light–dark cycle and exposed to hypoxia (1 atm, 10% O2). Implanted telemetry transmitters were used to record blood pressure (BP). Changes in heart rate (HR) and BP were monitored over a 21-day period, and variations before and during hypoxia were analyzed using the wavelet transform method. The HR, high-frequency power of HR variability (HR-HF) and low-frequency power of BP variability (BP-LF) were all significantly increased after 1 h of hypoxia, whereas the LF/HF ratio of HR variability did not change. After this initial increase, both HR and the BP-LF were found to decrease. On the first day of hypoxia, HR and BP-LF values were significantly lower than those of the control rats, whereas the HR-HF was higher. Subsequently, these values altered so that they were similar to the control after 14 days of hypoxia. In addition, the amplitude of diurnal variation in HR was reduced during hypoxia. These results suggest that a sequence of dynamic interactions between sympathetic and parasympathetic nervous activities might have important roles in the regulation of cardiovascular function during acclimatization to hypoxia.