Title of article
Requirement of intact sympathetic transmission for the ocular hypotensive effects of melatonin and 5-MCA-NAT
Author/Authors
Pilar Alarma-Estrany، نويسنده , , Almudena Crooke، نويسنده , , Assumpta Peral، نويسنده , , Jes?s Pintor، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
63
To page
66
Abstract
Melatonin and its analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), potently reduce intraocular pressure, and may be good candidates for the treatment of ocular hypertension and glaucoma. After chemical sympathectomy by reserpine or 6-hydroxydopamine, the hypotensive effects of melatonin and 5-MCA-NAT are severely inhibited. This indicates that the sympathetic nervous system is involved in the production and drainage of aqueous humour by the ciliary body and trabecular meshwork, and that it mediates the effects of melatonin and its analogue, 5-MCA-NAT.
Keywords
Melatonin , Glaucoma , intraocular pressure , 5-MCA-NAT , MT3 melatonin receptor
Journal title
Autonomic Neuroscience: Basic and Clinical
Serial Year
2007
Journal title
Autonomic Neuroscience: Basic and Clinical
Record number
476368
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