Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation

Japanese women show low incidence of and mortality from breast cancer, cardiovascular disease and climacteric symptoms compared to Caucasians. High soy bean intake is considered to attribute to that, but it is not clear whether soy protein itself or isoflavones (IFs) mixed in the soy protein has such effects. Presence of IFs in soy beans was varied by site, so we made IF-rich tablets from daidzein-rich soy germ (hypocotyl) for intervention studies. Our intervention study on young women by using the IF-rich tablet (20 and 40 mg/day) showed slight elongation of the menstrual cycle, but no adverse effects occurred. Intervention study on climacteric women showed improvement of bone density, hypertension and climacteric symptoms. Health effects of IFs on cancer occurrence, cardiovascular diseases, gynecological problems and possible immune potentiation are reviewed from functional aspects.