Title of article :
Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231
Author/Authors :
Hiroko Bando، نويسنده , , Masakazu Toi، نويسنده , , Kunio Kitada، نويسنده , , Morio Koike، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Hypoxia is a stress that causes alterations in signal transduction and gene instability. In the cancer microenvironment, hypoxia plays a significant role in forming a tumor phenotype and tumor progression. We aimed to identify the genes upregulated by hypoxia in human breast cancer cell lines, a hormone-dependent MCF-7 and a hormone-independent MDA-MB-231, using microarray analysis. These cells were exposed to two oxygen concentrations such as 21% and 1% in a time-course. Out of 12 625 genes, 26 genes were identified as commonly upregulated in both MCF-7 and MDA-MB-231 cells. Some of these genes were already reported as hypoxia-related, but some of those were identified newly. These commonly upregulated genes between hormone-dependent and hormone-independent cells would be a clue to study hypoxia-related events and to explore the novel therapeutic targets in human breast cancer.
Keywords :
hypoxia , breast cancer , Microarray
Journal title :
Biomedicine and Pharmacotherapy
Journal title :
Biomedicine and Pharmacotherapy