Title of article :
Stimulation of anti-melanoma immune effectors via modified tumour cells exhibiting inhibited IGF-I and low CD9
Author/Authors :
Severine Trabado، نويسنده , , Pascale Nguyen Van Binh، نويسنده , , Chantal Martin، نويسنده , , Christiane Lafarge-Frayssinet، نويسنده , , Yu-Chun Lone، نويسنده , , Jerzy Trojan، نويسنده , , Jean-Michel Warnet، نويسنده , , Huynh Thien Duc، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Modified melanoma cells (B16-F0.MOD) characterized by inhibited IGF-I, CD9 low but not their wild-type counterparts (B16-F0.WT), IGF-I positive, CD9 high, were shown to be immunogenic for syngeneic hosts. C57BL/6 syngeneic recipients vaccinated with B16-F0.MOD cells developed immune effectors that were observed at the humoral as well as cellular levels. These immune effectors were shown to be capable of controlling in vitro tumour growth and in vivo tumour progression.
Keywords :
Modified melanoma cells , Cellular/humoral immune effectors
Journal title :
Biomedicine and Pharmacotherapy
Journal title :
Biomedicine and Pharmacotherapy
