Title of article :
Effect of amlodipine, atenolol and their combination on myocardial ischemi during treadmill exercise and ambulatory monitoring
Author/Authors :
Richard F. Davies، نويسنده , , Habibullah Habibi، نويسنده , , W. Peter Klinke، نويسنده , , Pierre Dessain، نويسنده , , Claude Nadeau، نويسنده , , Denis C. Phaneuf، نويسنده , , Serge Lepage، نويسنده , , Sankaranarayanan Raman، نويسنده , , Margaret Herbert، نويسنده , , Kathy Foris، نويسنده , , Wolfgang Linden، نويسنده , , Jennifer A. Buttars and For the Canadian Amlodipine/atenolol In Silent Ischemi Study (CASIS) Investigators، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
7
From page :
619
To page :
625
Abstract :
Objectives. This study compared the effects of amlodipine, atenolol and their combination on ischemi during treadmill testing and 48-h ambulatory monitoring. Background. It is not known whether anti-ischemic drugs exert similar effects on ischemi during ambulatory monitoring and exercise treadmill testing. Methods. Patients with stable coronary artery disease and ischemi during treadmill testing and ambulatory monitoring were randomized to receive amlodipine (n = 51) or atenolol (n = 49). Each group underwent counterbalanced, crossover evaluation of single drug and placebo, followed by evaluation of the combination. Results. Amlodipine and the combination prolonged exercise time to 0.1-mV ST segment depression by 29% and 34%, respectively (p < 0.001) versus 3% for atenolol (p = NS). During ambulatory monitoring, the frequency of ischemic episodes decreased by 28% with amlodipine (p = 0.083 [NS]), by 57% with atenolol (p < 0.001) and by 72% with the combination (p < 0.05 vs. both single drugs; p < 0.001 vs. placebo). Suppression of ischemi during exercise testing and ambulatory monitoring was similar in patients with and without exercise-induced angina. Exercise time to angin improved by 29% with amlodipine (p < 0.01), by 16% with atenolol (p < 0.05) and by 39% with the combination (p < 0.005 vs. placebo, atenolol and amlodipine). In patients with angina, total exercise time improved by 16% with amlodipine (p < 0.001), by 4% with atenolol (p = NS) and by 19% with the combination (p < 0.05 vs. placebo and either single drug). In those patients without angina, no therapy significantly improved total exercise time. Conclusions. Ischemi during treadmill testing was more effectively suppressed by amlodipine, whereas ischemi during ambulatory monitoring was more effectively suppressed by atenolol. The combination was more effective than either single drug in both settings
Journal title :
JACC (Journal of the American College of Cardiology)
Serial Year :
1995
Journal title :
JACC (Journal of the American College of Cardiology)
Record number :
478429
Link To Document :
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