Blood Pressure Changes During Transient Myocardial Ischemia: Insights Into Mechanisms

Objectives. We investigated the contribution of changes in systemic blood pressure to the genesis of spontaneous myocardial ischemia. Background. Although increases in heart rate often precede the development of spontaneous myocardial ischemia, it remains subject of controversy whether these are accompanied by simultaneous changes in blood pressure. Methods. Using an ambulatory monitoring device that triggered blood pressure recordings from the level of the ST segment, we documented systolic and diastolic blood pressure and heart rate changes related to episodes of ST segment depression in 17 patients with stable coronary artery disease. Results. Systolic blood pressure and heart rate, but not diastolic pressure, increased significantly before the onset of ST segment depression and persisted throughout the ischemic episode. There was significant correlation between the changes in heart rate and systolic blood pressure during episodes of myocardial ischemi (r = 0.5, p = 0.0005) and between heart rate and systolic blood pressure changes at 1-mm ST segment depression during treadmill exercise testing and ambulatory monitoring (r = 0.73, p = 0.0005 for heart rate; r = 0.77, p = 0.0008 for systolic blood pressure), indicating that patients with low heart rate threshold during ischemic episodes also had lower systolic blood pressure threshold before ischemi during both tests. Circadian changes in systolic blood pressure paralleled the variations in heart rate and ischemic episodes, with the lowest values at night. Conclusions. Significant increases in myocardial oxygen demand, including systolic blood pressure, occur during episodes of spontaneous myocardial ischemia. Patients with lower heart rate threshold during ischemic episodes had lower systolic blood pressure threshold during both ambulatory monitoring and treadmill exercise. The effects of antianginal therapy on blood pressure changes during ischemi need to be explored further.