Recovery of contractility of viable myocardium during inotropic stimulation is not dependent on an increase of myocardial blood flow in the absence of collateral filling

OBJECTIVES The purpose of this study was to determine whether contractile recovery induced by dobutamine in dysfunctioning viable myocardium supplied by nearly occluded vessels is related to an increase in blood flow in the absence of collaterals. BACKGROUND Dobutamine is used to improve contractility in ventricular dysfunction during acute myocardial infarction. However, it is unclear whether significant increase in regional blood flow may be involved in dobutamine effect. METHODS Twenty patients with 5- to 10-day old anterior infarction and ≥90% left anterior descending coronary artery stenosis underwent 99mTc-Sestamibi tomography (to assess myocardial perfusion) at rest and during low dose (5 to 10 μg/kg/min) dobutamine echocardiography. Rest echocardiography and scintigraphy were repeated >1 month after revascularization. Nine patients had collaterals to the infarcted territory (group A), and 11 did not (group B). RESULTS Baseline wall motion score was similar in both groups (score 15.9 ± 1.3 vs. 17.4 ± 2.0, p = NS), whereas significant changes at dobutamine and postrevascularization studies were detected (F[2,30] = 409.79, p < 0.0001). Wall motion score improved significantly (p < 0.001) in group both at dobutamine (−5.3 ± 2.2) and at postrevascularization study (−5.5 ± 1.9), as well as in group B (−3.9 ± 2.8 and −4.5 ± 2.4, respectively). Baseline 99mTc-Sestamibi uptake was similar in both groups (62.9 ± 9.7% vs. 60.3 ± 10.4%, p = NS), whereas at dobutamine and postrevascularization studies significant change (F[2,30] = 65.17, p < 0.0001) and interaction between the two groups (F[2,30] = 33.14, p < 0.0001) were present. Tracer uptake increased significantly in group both at dobutamine (+10.9 ± 7.9%, p < 0.001) and at postrevascularization study (12.1 ± 8.7%, p < 0.001). Conversely, group B patients showed no change in tracer uptake after dobutamine test (−0.4 ± 5.8, p = NS), but only after revascularization (+8.8 ± 7.2%, p < 0.001). CONCLUSIONS The increase in contractility induced by low dose dobutamine infusion in dysfunctional viable myocardium supplied by nearly occluded vessels occurs even in the absence of significant increase in blood flow.